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Rheumatology Advance Access published online on April 30, 2003
Rheumatology, doi:10.1093/rheumatology/keg304
Rheumatology © British Society for Rheumatology 2003; all rights reserved
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© 2003 British Society for Rheumatology 2003; all rights reserved

Original Papers

Psoriasis vulgaris and psoriatic arthritis share a 100 kb susceptibility region telomeric to HLA-C

J. Martínez-Borra 1, S. González 2, J. Santos-Juanes 3, J. Sánchez del Río 3, J. C. Torre-Alonso 4, A. López-Vázquez 1, M. A. Blanco-Geláz 1, C. López-Larrea 1*

1 Department of Immunology, Hospital Central de Asturias
2 Department of Functional Biology, University of Oviedo
3 Department of Dermatology, Hospital Central de Asturias
4 Hospital Monte Naranco, Oviedo, Spain

* Corresponding author. E-mail: inmuno{at}hca.es.

Received 12 August 2002 ; accepted 5 February 2003

Abstract

Objective. To map the locus for susceptibility to psoriasis in patients with psoriatic arthritis.

Methods. Seventy-four patients with psoriatic arthritis and 95 patients with psoriasis vulgaris were included in this study. Polymorphic genes and microsatellite markers centromeric (C1_2_5) and telomeric (C1_4_4, OTF3, HCR and the corneodesmosin gene) to HLA-C were studied in an association analysis. Typing was also performed on a control population of 104 matched donors.

Results. The allele Cw*0602 was associated both with psoriasis [49 vs 21%, Pc<0.0003; odds ratio (OR)=3.6, aetiological factor (AF)=0.72] and with psoriatic arthritis (62 vs 21%, Pc<0.000001; OR=6.1, AF=0.83). In psoriatic patients a susceptibility region telomeric to HLA-C that includes C1_4_4 (56 vs 22%, Pc<0.0002; OR=4.39, AF=0.77), OTF3 (85 vs 60%, Pc<0.0002; OR=3.7, AF=0.73) and HCR (63 vs 26%, Pc<0.00001; OR=3.8, AF=0.74) was observed. In psoriatic arthritis patients the susceptibility region was delimited by HLA-C and C1_4_4 (384 allele, 56 vs 22%, Pc<0.0002; OR=4.37, AF=0.77).

Conclusions. Comparing the susceptibility regions associated with the two diseases, an overlapping interval of 100 kb between HLA-C and OTF3, which might contain the psoriasis gene, can be defined.

Key words: Psoriatic arthritis, Psoriasis vulgaris, HLA-C, C1_4_4.
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