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Rheumatology Advance Access published online on May 30, 2003
Rheumatology, doi:10.1093/rheumatology/keg316
Rheumatology © British Society for Rheumatology 2003; all rights reserved
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© 2003 Rheumatology 42 © British Society for Rheumatology 2003; all rights reserved

Original Papers

Paucity of Sjögren-like syndrome in a cohort of HIV-1-positive patients in the HAART era. Part II

G. D. Panayiotakopoulos 1, K. Aroni 2, D. Kyriaki 3, S. Paikos 4, N. Vouyioukas 5, A. Vlachos 5, A. N. Kontos 6, T. Kordossis 6*

1 Academic Department of Pathophysiology (AIDS Unit), School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
2 Academic Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
3 Laboratory of Nuclear Medicine, Laikon General Hospital, Athens, Greece
4 Dental Clinic, Laikon General Hospital, Athens, Greece
5 Eye Clinic, Laikon General Hospital, Athens, Greece
6 Academic Departments of Pathophysiology (AIDS Unit), School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

* Corresponding author. E-mail: tkordoss{at}med.uoa.gr.

Received 14 September 2002 ; accepted 12 February 2003

Abstract

Objective. This study was performed in order to investigate the prevalence of Sjögren-like syndrome (SLS) in the highly active anti-retroviral therapy (HAART) era in a cohort of HIV-1-positive Greek patients.

Methods. One hundred and thirty-one unselected patients were screened by the validated European Union (EU) criteria for Sjögren's syndrome. Of the 31 who gave a positive EU-validated questionnaire, 17 consented to undergo minor salivary gland biopsy and other tests.

Results. Only two patients had a positive salivary gland biopsy and both belonged to the non-compliant HAART group, whereas none of the compliant HAART patients had histological findings.

Conclusions. It is concluded that SLS, the prevalence of which in the pre-HAART era was 7.8%, has disappeared, possibly as a result of the protective action of HAART.

Key words: Sjögren-like syndrome, HIV infection, HAART, Pathology.
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