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Rheumatology Advance Access published online on July 30, 2003
Rheumatology, doi:10.1093/rheumatology/keg362
Rheumatology © British Society for Rheumatology 2003; all rights reserved
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© 2003 © 2003 British Society for Rheumatology

Report

Salivary gland involvement in rheumatoid arthritis and its relationship to induced oxidative stress

R. M. Nagler 1*, F. Salameh 2, A. Z. Reznick 3, V. Livshits 4, and A. M. Nahir 4

1 Oral Biochemistry Laboratory and Salivary Clinic, Department of Oral and Maxillofacial Surgery, Rambam Medical Center and The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Department of Anatomy and Cell Biology, Rambam Medical Center and The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
2 Oral Biochemistry Laboratory and Salivary Clinic, Department of Oral and Maxillofacial Surgery, Rambam Medical Center and The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; B. Shine Department of Rheumatology, Rambam Medical Center and The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
3 Department of Anatomy and Cell Biology, Rambam Medical Center and The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
4 B. Shine Department of Rheumatology, Rambam Medical Center and The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

* Corresponding author. E-mail: nagler{at}tx.technion.ac.il.

Received 23 August 2002 ; accepted 5 March 2003

Abstract

Objectives. The objective of the present study was to analyse salivary gland and free radical involvement in rheumatoid arthritis (RA).

Methods. Thirty-four consenting RA patients (rheumatoid factor-positive) and 18 healthy controls, matched in age and gender, participated in the study. Plasma and saliva samples were harvested and subjected to compositional analysis and various free radical-related tests.

Results. The mean salivary flow rate was lower in the RA patients than in the control group, whereas all plasma and salivary antioxidants were increased. Mean values of plasma malondialdehyde and ceruloplasmin were higher in the RA patients.

Conclusions. The effects of RA on salivary gland flow rates and antioxidant compositional parameters may be of great importance for the further elucidation of the role of free radicals in RA pathogenesis and for its general diagnosis and evaluation. The demonstrated correlation between the altered salivary parameters and the severity of the disease may indicate that evaluation of the salivary status of RA patients is warranted.

Key words: Saliva, Antioxidants, Rheumatoid arthritis, Total antioxidant status, Peroxidase, Uric acid, Malondialdehyde, Ceruloplasmin, Creatinine.
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