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Rheumatology Advance Access published online on June 16, 2003
Rheumatology, doi:10.1093/rheumatology/keg383
Rheumatology © British Society for Rheumatology 2003; all rights reserved
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© 2003 Rheumatology 42 © British Society for Rheumatology 2003; all rights reserved

Original Papers

CARD15/NOD2 analysis in rheumatoid arthritis susceptibility

I. Ferreirós-Vidal 1, F. Barros 2, J. L. Pablos 3, A. Carracedo 2, J. J. Gómez-Reino 1, and A. Gonzalez 1*

1 Research Laboratory 2 and the Rheumatology Unit, Hospital Clinico Universitario de Santiago, Spain
2 Molecular Medicine Unit-INGO-Universidad de Santiago de Compostela, Spain
3 Rheumatology Unit, Hospital 12 de Octubre, Madrid, Spain

* Corresponding author. E-mail: gon2906{at}globalum.com.

Received 23 October 2002 ; accepted 19 March 2003

Abstract

Objective. To determine if the mutations in the CARD15/NOD2 gene predisposing to Crohn's disease (CD) contribute also to the genetic susceptibility to rheumatoid arthritis (RA).

Methods. The frequencies of the three commonest mutations of CARD15/NOD2 predisposing to CD (2104C > T, 2722G>C and 3020insC) were determined in 210 RA patients and 227 controls.

Results. Allelic frequencies of the CARD15/NOD2 mutations in RA patients (2104C>T, 2.8%; 2722G>C, 0.9%; and 3020insC, 2.4%) did not differ significantly from the controls (2104C>T, 5.3%; 2722G>C, 0.7%; and 3020insC, 1.1%).

Conclusion. There was no evidence of association between the commonest CD CARD15/NOD2 mutations and RA susceptibility.

Key words: Rheumatoid arthritis, Crohn's disease, Genetic predisposition to disease, Autoimmune diseases.
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