Skip Navigation



Rheumatology Advance Access published online on July 16, 2003
Rheumatology, doi:10.1093/rheumatology/keg423
Rheumatology © British Society for Rheumatology 2003; all rights reserved
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
42/12/1534    most recent
keg423v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Julià, A.
Right arrow Articles by Marsal, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Julià, A.
Right arrow Articles by Marsal, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2003 © 2003 British Society for Rheumatology

Original Papers

Association study between corticotrophin-releasing hormone genomic region (8q13) and rheumatoid arthritis in the Spanish population

A. Julià 1, D. Gallardo 2, F. Vidal 2, J. J. De 1, P. Barceló 1, M. Vilardell 3, and S. Marsal 1*

1 Hospital General i Universitari Vall d'Hebron, Unitat de Reumatologia, Barcelona, Spain
2 Centre de Transfusions i Banc de Teixits (CTBT), ICS, Barcelona, Spain
3 Hospital General i Universitari Vall d'Hebron, Servei de Medicina Interna, Barcelona, Spain

* Corresponding author. E-mail: saramarsal{at}eresmas.com.

Received 27 September 2002 ; accepted 28 April 2003

Abstract

Objective. To investigate whether the corticotrophin-releasing hormone (CRH) genomic region confers genetic susceptibility to rheumatoid arthritis (RA) in the Spanish population.

Methods. DNA was obtained from 121 simplex RA families and 101 healthy controls, all from Spanish origin. Two microsatellites, CRHRA1 and CRHRA2, located 25 and 20 kb downstream respectively from the CRH gene were examined using a new multiplex design. Linkage disequilibrium (LD) between the markers was assessed and association studies were carried out using the transmission disequilibrium test (TDT) implemented in TRANSMIT.

Results. Both markers are in Hardy-Weinberg equilibrium and there is significant LD between them in the Spanish population. Neither the polymorphic alleles of CRHRA1 and CRHRA2 markers nor their resulting haplotypes were significantly associated to RA. The associated haplotype in the UK population (CRHRA1*10; CRHRA2*14) was undertransmitted in RA patients (12 obs vs 17.43 exp), although the difference is not statistically significant (P > 0.05).

Conclusions. This is the first follow-up study of the association between the CRH genomic region and RA and suggests that the CRH gene may not be involved in the pathogenesis of RA in the Spanish population. Further studies in other populations will help untangle the real contribution of this genomic region to the susceptibility to RA.

Key words: Rheumatoid Arthritis, susceptibility, association, Transmission Disequilibrium Test, CRH microsatellite
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.