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Rheumatology Advance Access published online on August 15, 2003
Rheumatology, doi:10.1093/rheumatology/keg426
Rheumatology © British Society for Rheumatology 2003; all rights reserved
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© 2003 Rheumatology 42 © British Society for Rheumatology 2003; all rights reserved

Original Papers

Magnetic resonance imaging measurement of knee cartilage volume in a multicentre study

S. R. Morgan 1*, J. C. Waterton 1, R. A. Maciewicz 1, J. E. Leadbetter 1, S. J. Gandy 2, R. J. Moots 3, P. Creamer 4, and A. F. P. Nash 1

1 AstraZeneca, Macclesfield, UK
2 Department of Medical Physics, Ninewells Hospital, Dundee, UK
3 Rheumatology Research Group, University Hospital Aintree, Liverpool, UK
4 Department of Rheumatology, Southmead Hospital, Bristol, UK

* Corresponding author. E-mail: shethah.morgan{at}astrazeneca.com.

Received 19 September 2002 ; accepted 23 April 2003

Abstract

Objective. To investigate the variability between different high-field scanners in magnetic resonance imaging (MRI) measurement of knee cartilage volume in healthy female volunteers.

Methods. Five volunteers had both knees scanned using three different MRI scanners. Cartilage volume in each compartment was measured from the images by image segmentation. The data were analysed using analysis of variance models.

Results. The mean total cartilage volume of the 10 knees scanned at three different centres was 16.15, 16.40 and 15.63 ml for the Siemens, GE and Philips scanners respectively. Small systematic differences were seen in the total knee cartilage volume results.

Conclusions. Although there were small systematic differences in knee cartilage volume, the three MRI scanners gave broadly similar results.

Key words: MRI, Knee cartilage, Multicentre clinical trials.
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