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Rheumatology Advance Access published online on August 29, 2003
Rheumatology, doi:10.1093/rheumatology/keg468
Rheumatology © British Society for Rheumatology 2003; all rights reserved
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© 2003 Rheumatology 42 © British Society for Rheumatology 2003; all rights reserved

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Cardiovascular autonomic dysfunction in primary Sjögren's syndrome

László Kovács 1*, Dóra Paprika 2, Róbert Takács 3, Attila Kardos 4, Tamás T. Várkonyi 3, Csaba Lengyel 3, Attila Kovács 1, László Rudas 2, and Gyula Pokorny 1

1 Department of Rheumatology, University of Szeged, Faculty of Medicine, Szeged, Hungary
2 Intensive Care Unit of the 2nd Department of Internal Medicine and Cardiology Centre, University of Szeged, Faculty of Medicine, Szeged, Hungary
3 1st Department of Internal Medicine, University of Szeged, Faculty of Medicine, Szeged, Hungary
4 Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK

* Corresponding author. E-mail: kovl{at}in1st.szote.u.

Received 8 January 2003 ; accepted 20 June 2003

Abstract

Objective. To assess the occurrence and clinical significance of a cardiovascular autonomic nervous system dysfunction in primary Sjögren's syndrome (pSS).

Methods. Fifty-one pSS patients participated in this case-control study. Heart rate and blood pressure variability measurements, spontaneous baroreflex sensitivity examinations and cardiovascular reflex tests were performed.

Results. The results of the heart rate and blood pressure variability measurements and also the baroreflex sensitivity parameters of the pSS patients peaked in the lowest percentile ranges of a database on 559 healthy control subjects (P < 0.05). In three of the five cardiovascular reflex tests, the frequencies of abnormal results were significantly higher among the patients than among the controls (P < 0.05), and the median autonomic neuropathy score was also elevated (3 vs 0 in the controls; P < 0.0001).

Conclusion. Signs of an autonomic nervous system dysfunction involving the cardiovascular system can be discerned in the majority of pSS patients.

Key words: Antireceptor antibody, Autonomic dysfunction, Baroreflex sensitivity, Blood pressure variability, Cardiovascular reflex test, Heart rate variability, Primary Sjögren's syndrome.
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