Rheumatology Advance Access published online on January 13, 2004
Rheumatology, doi:10.1093/rheumatology/keh082
Rheumatology © British Society for Rheumatology 2004; all rights reserved
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Original Papers
1 Juvenile Dermatomyositis Research Centre, Institute of Child Health, Great Ormond Street, London, UK
* Corresponding author. E-mail: C.Pilkington{at}ich.ucl.ac.uk.
Received 27 June 2003
; accepted 22 October 2003
Objectives. To assess the efficacy and safety of intravenous cyclophosphamide (CYP) used in severe and refractory juvenile dermatomyositis (JDM). Methods. Retrospective case note review of the outcome of 12 patients. Results. Assessment at 6 months of therapy in 10 of the 12 patients showed a significant improvement in muscle function as assessed by the Childhood Myositis Assessment Scale (CMAS) (P = 0.012), muscle strength (P = 0.008), global extramuscular disease score (P = 0.008), skin disease severity (P = 0.015) and lactate dehydrogenase (P = 0.028). There were reductions in creatine kinase, alanine aminotransferase, prednisolone dose and ESR, but these did not reach statistical significance. Clinical improvement was maintained after CYP until the most recent follow-up (between 6 months and 7 yr) and no severe side-effects were seen. Reversible complications included lymphopenia, herpes zoster infections and alopecia. The median cumulative dose was 4.6 g/m2 (range 3-9 g/m2). The available evidence suggests that, at the doses required, risks of malignancy, infertility and gonadal failure are low. Two patients with severe treatment-resistant disease died after one dose of CYP, both of whom were ventilated prior to commencement of CYP and were thought to have died as a result of their severe disease process, and too early for clinical benefit to be obtained from the drug. Conclusions. In this cohort of children with severe and refractory JDM, CYP appeared to have provided major clinical benefit with no evidence of serious toxicity in the short term.
Key words: Juvenile, Dermatomyositis, Cyclophosphamide, Refractory, Ulcerative, Childhood, Vasculitis, Interstitial lung, Gastrointestinal.
Intravenous cyclophosphamide pulse therapy in juvenile dermatomyositis. A review of efficacy and safety
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