Rheumatology Advance Access published online on February 17, 2004
Rheumatology, doi:10.1093/rheumatology/keh143
Rheumatology © British Society for Rheumatology 2004; all rights reserved
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Original Papers
1 Immunology and Rheumatology Services, Hospital Universitario Marqués de Valdecilla, Facultad de Medicina, Universidad de Cantabria, Santander, Spain
* Corresponding author. E-mail: vmartinezt{at}medynet.com.
Received 18 November 2003
; accepted 8 January 2004
Background. In a significant number of patients the differential diagnosis between elderly-onset rheumatoid arthritis (EORA) and polymyalgia rheumatica (PMR) is very difficult because of the lack of specific serum markers. Anti-cyclic citrullinated peptide antibodies (anti-CCP Abs) have recently been shown to be highly specific for rheumatoid arthritis (RA). This is the first study addressing the utility of these antibodies in the differential diagnosis between EORA and PMR. Methods. Serum samples from 57 EORA patients and 49 PMR patients were studied for the presence of anti-CCP Abs and rheumatoid factor (RF). As controls, samples from 41 RA patients (age at onset <60 yr) and 24 aged healthy subjects were analysed. Results. Sixty-five per cent of EORA patients had anti-CCP Abs, whereas none of the PMR patients or the aged healthy subjects was positive for those antibodies. Ten of the EORA patients started with polymyalgic symptoms and two of them were positive for anti-CCP Abs. Interestingly, there was a significant correlation between anti-CCP Abs and RF in EORA but not in young RA patients. Conclusions. The presence of anti-CCP Abs in a patient with clinical symptoms of PMR must be interpreted as highly suggestive of EORA.
Key words: Polymyalgia rheumatica, Rheumatoid arthritis, Elderly, Anti-CCP antibodies.
Clinical utility of anti-CCP antibodies in the differential diagnosis of elderly-onset rheumatoid arthritis and polymyalgia rheumatica
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. T. Pease, G. Haugeberg, B. Montague, E. M. A. Hensor, B. B. Bhakta, W. Thomson, W. E. R. Ollier, and A. W. Morgan Polymyalgia rheumatica can be distinguished from late onset rheumatoid arthritis at baseline: results of a 5-yr prospective study Rheumatology, February 1, 2009; 48(2): 123 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Anzilotti, L. Riente, F. Pratesi, D. Chimenti, A. Delle Sedie, S. Bombardieri, and P. Migliorini IgG, IgA, IgM antibodies to a viral citrullinated peptide in patients affected by rheumatoid arthritis, chronic arthritides and connective tissue disorders Rheumatology, October 1, 2007; 46(10): 1579 - 1582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nishimura, D. Sugiyama, Y. Kogata, G. Tsuji, T. Nakazawa, S. Kawano, K. Saigo, A. Morinobu, M. Koshiba, K. M. Kuntz, et al. Meta-analysis: Diagnostic Accuracy of Anti-Cyclic Citrullinated Peptide Antibody and Rheumatoid Factor for Rheumatoid Arthritis Ann Intern Med, June 5, 2007; 146(11): 797 - 808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Cutolo, C M Montecucco, L Cavagna, R Caporali, S Capellino, P Montagna, L Fazzuoli, B Villaggio, B Seriolo, and A Sulli Serum cytokines and steroidal hormones in polymyalgia rheumatica and elderly-onset rheumatoid arthritis Ann Rheum Dis, November 1, 2006; 65(11): 1438 - 1443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. W. Zendman, W. J. van Venrooij, and G. J. M. Pruijn Use and significance of anti-CCP autoantibodies in rheumatoid arthritis Rheumatology, January 1, 2006; 45(1): 20 - 25. [Full Text] [PDF]
|
|