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Rheumatology Advance Access first published online on June 15, 2004
This version published online on June 29, 2004
Rheumatology, doi:10.1093/rheumatology/keh256
Rheumatology © British Society for Rheumatology 2004; all rights reserved
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Received January 13, 2004
Accepted May 11, 2004

Original Papers

Which cartilage is regenerated, hyaline cartilage or fibrocartilage? Non-invasive ultrasonic evaluation of tissue-engineered cartilage

K. Hattori 1*, Y. Takakura 1, H. Ohgushi 2, T. Habata 1, K. Uematsu 1, M. Takenaka 3, K. Ikeuchi 3

1 Department of Orthopaedic Surgery, Nara Medical University, 840, Shijyo-cho, Kashihara, Nara, 634-8522, Japan
2 National Institute of Advanced Industrial Science and Technology, Amagasaki Site, 3-11-46, Wakaouji, Amagasaki, Hyogo 661-0974, Japan
3 Institute for Frontier Medical Sciences, Kyoto University, 53, Shogoin Kawahara-cho, Kyoto 606-8397, Japan

* To whom correspondence should be addressed. E-mail: hattori{at}naramed-u.ac.jp.


  Abstract

Objective. To investigate ultrasonic evaluation methods for detecting whether the repair tissue is hyaline cartilage or fibrocartilage in new cartilage regeneration therapy.

Methods. We examined four experimental rabbit models: a spontaneous repair model (group S), a large cartilage defect model (group L), a periosteal graft model (group P) and a tissue-engineered cartilage regeneration model (group T). From the resulting ultrasonic evaluation, we used %MM (the maximum magnitude of the measurement area divided by that of the intact cartilage) as a quantitative index of cartilage regeneration. The results of the ultrasonic evaluation were compared with the histological findings and histological score.

Results. The %MM values were 61.1 ± 16.5% in group S, 29.8 ± 15.1% in group L, 36.3 ± 18.3% in group P and 76.5 ± 18.7% in group T. The results showed a strong similarity to the histological scoring.

Conclusion. The ultrasonic examination showed that all the hyaline-like cartilage in groups S and T had a high %MM (more than 60%). Therefore, we could define the borderline between the two types of regenerated cartilage by the %MM.

Keywords: Ultrasound; Articular cartilage; Evaluation; Hyaline cartilage; Tissue engineering.
This article is a corrected version of that originally published. H. Ohgushi was previously spelled incorrectly as H. Ohgishi. The authors would like to apologize for this error.
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