Skip Navigation



Rheumatology Advance Access published online on August 3, 2004
Rheumatology, doi:10.1093/rheumatology/keh344
Rheumatology © British Society for Rheumatology 2004; all rights reserved
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
44/1/7    most recent
keh344v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Bonnet, C. S.
Right arrow Articles by Walsh, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bonnet, C. S.
Right arrow Articles by Walsh, D. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Received February 27, 2004
Accepted June 28, 2004

Review

Osteoarthritis, angiogenesis and inflammation

C. S. Bonnet 1 D. A. Walsh 1*

1 Academic Rheumatology, University of Nottingham, Nottingham City Hospital, Nottingham, UK

* To whom correspondence should be addressed. E-mail: David.Walsh{at}nottingham.ac.uk.


  Abstract

Angiogenesis and inflammation are closely integrated processes in osteoarthritis (OA) and may affect disease progression and pain. Inflammation can stimulate angiogenesis, and angiogenesis can facilitate inflammation. Angiogenesis can also promote chondrocyte hypertrophy and endochondral ossification, contributing to radiographic changes in the joint. Inflammation sensitizes nerves, leading to increased pain. Innervation can also accompany vascularization of the articular cartilage, where compressive forces and hypoxia may stimulate these new nerves, causing pain even after inflammation has subsided. Inhibition of inflammation and angiogenesis may provide effective therapeutics for the treatment of OA by improving symptoms and retarding joint damage. This review aims to summarize (i) the evidence that angiogenesis and inflammation play an important role in the pathophysiology of OA and (ii) possible directions for future research into therapeutics that could effectively treat this disease.

Keywords: Osteoarthritis; Synovitis; Angiogenesis; Innervation; Osteophyte; Macrophage; Chondrocalcinosis.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Rheumatology (Oxford)Home page
R. M. Aspden
Osteoarthritis: a problem of growth not decay?
Rheumatology, October 1, 2008; 47(10): 1452 - 1460.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
D. McGonagle, A. L. Tan, A. J. Grainger, and M. Benjamin
Heberden's nodes and what Heberden could not see: the pivotal role of ligaments in the pathogenesis of early nodal osteoarthritis and beyond
Rheumatology, September 1, 2008; 47(9): 1278 - 1285.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
E. Anitua, M. Sanchez, A. T. Nurden, M. M. Zalduendo, M. de la Fuente, J. Azofra, and I. Andia
Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients
Rheumatology, December 1, 2007; 46(12): 1769 - 1772.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
J. D. Rees, A. M. Wilson, and R. L. Wolman
Current concepts in the management of tendon disorders
Rheumatology, May 1, 2006; 45(5): 508 - 521.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.