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Rheumatology Advance Access published online on April 6, 2005
Rheumatology, doi:10.1093/rheumatology/keh630
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received June 14, 2004
Accepted March 1, 2005

Concise Report

Relationship between rheumatoid arthritis and Mycoplasma pneumoniae: a case-control study

A. S. Ramírez 1*, A. Rosas 2, J. A. Hernández-Beriain 2, J. C. Orengo 3, P. Saavedra 4, C. de la Fe 1, A. Fernández 5, and J. B. Poveda 1

1 Unit of Epidemiology and Preventive Medicine, Veterinary Faculty, University of Las Palmas, Trasmontaña s/n, 35416, Arucas, Las Palmas de Gran Canaria, Spain
2 Rheumatology Section, Hospital Insular de Gran Canaria, Spain
3 Investigation Unit, Hospital Insular de Gran Canaria, Spain
4 Mathematics Department, University of Las Palmas, Trasmontaña s/n, 35416, Arucas, Las Palmas de Gran Canaria, University of Las Palmas, Trasmontaña s/n, 35416, Arucas, Las Palmas de Gran Canaria, Spain
5 Department of Histology and Pathology, University of Las Palmas, Trasmontaña s/n, 35416, Arucas, Las Palmas de Gran Canaria, Spain

* To whom correspondence should be addressed.
A. S. Ramírez, E-mail: aramirez{at}dpat.ulpgc.es


  Abstract

Objective. Rheumatoid arthritis (RA) has a complex and multifactorial aetiology. Infectious agents could start this disease. The majority of the characteristics of this infirmity can be observed in chronic arthritis produced by mycoplasmas in animals. In this study the association between Mycoplasma pneumoniae and RA has been evaluated.

Methods. A case-control study was performed. Sera taken from 78 RA patients and from 156 controls were analysed to ascertain the levels of immunoglobulin G (IgG) against M. pneumoniae. Other variables, like age, gender, work status, history of pneumonia, etc., were recorded in a questionnaire.

Results. The presence of antibodies against M. pneumoniae was associated with RA (odds ratio=2.34, P<0.001).

Conclusions. The results suggest that M. pneumoniae could be a cofactor in the pathogenesis of RA; however, more studies need to be done.

Keywords: Case-control studies; Rheumatoid arthritis; Mollicutes; Mycoplasma pneumoniae; ELISA.
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