Rheumatology Advance Access published online on May 18, 2005
Rheumatology, doi:10.1093/rheumatology/keh689
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Departments of Paediatrics, University of Manitoba, Winnipeg, Manitoba, Canada
* To whom correspondence should be addressed. Objectives. Single nucleotide polymorphisms (SNPs) in cytokine genes have been associated with risk of a number of autoimmune diseases. Moreover, some SNPs are associated with variations in rates of in vitro gene expression, and it is therefore possible that these functional polymorphisms may differentially affect inflammatory processes and disease outcome. This project's objective was to determine whether cytokine genotypes correlate with disease outcomes in patients with juvenile rheumatoid arthritis (JRA). Methods. Genotypes of SNPs of pro-inflammatory cytokines, tumour necrosis factor- Results. In multivariate tests, the IL-6 genotype -174G/G was positively correlated with pain [regression coefficient B = 0.899, 95% confidence intervals (CI) 0.185, 1.612, P = 0.014]. The homozygous TGF- Conclusions. The correlation of IL-6 genotype with pain and the possible association of the TGF-
Received January 24, 2005
Accepted April 26, 2005
Original Papers
Cytokine genotypes correlate with pain and radiologically defined joint damage in patients with juvenile rheumatoid arthritis
2 Department of Paediatrics, University of British Columbia, Vancouver, British Columbia, Canada
3 Department of Paediatrics, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
4 Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; Canadian Blood Transfusion Service, Winnipeg, Manitoba, Canada
5 Radiology, University of Manitoba, Winnipeg, Manitoba, Canada
K. Oen, E-mail: koen{at}exchange.hsc.mb.ca
Abstract 
-308G 
A, interleukin-6 (IL-6) -174G C and interferon-gamma +874G A, and anti-inflammatory, immunosuppressive cytokines, interleukin-10 -1082G A, -819C T and -592A C and transforming growth factor-
1 (TGF-1) codon 10T C and codon 25G C, were determined for patients with JRA who previously participated in a long-term outcome study. Cytokine genotypes and clinical variables showing significant correlations with clinical outcomes at the = 0.100 level in univariate analyses were entered in multivariate tests.1 codon 25G/G genotype showed a protective effect against joint space narrowing on radiographs taken within 2 yr of disease onset, but confidence intervals were wide [odds ratio (OR) 0.176, 95% CI 0.037, 0.837 P = 0.029].1 codon 25 genotype with short-term radiographic damage (G/C with greater risk and G/G with decreased risk) suggests that both these polymorphisms may be useful early prognostic indicators. Further studies of the relation between cytokine genotypes and outcomes in patients with all forms of juvenile idiopathic arthritis (JIA) are warranted.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. Cimaz, M.-A. Cazalis, C. Reynaud, V. Gerloni, F. Zulian, M. Biggioggero, G. Martini, I. Pontikaki, F. Fantini, B. Mougin, et al. IL1 and TNF gene polymorphisms in patients with juvenile idiopathic arthritis treated with TNF inhibitors Ann Rheum Dis, July 1, 2007; 66(7): 900 - 904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Peake, K. Khawaja, A. Myers, M. A. Nowell, S. A. Jones, A. D. Rowan, T. E. Cawston, and H. E. Foster Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor Rheumatology, December 1, 2006; 45(12): 1485 - 1489. [Abstract] [Full Text] [PDF]
|
|