Skip Navigation



Rheumatology Advance Access published online on June 21, 2005
Rheumatology, doi:10.1093/rheumatology/keh719
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
44/10/1227    most recent
keh719v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Sturfelt, G.
Right arrow Articles by Truedsson, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sturfelt, G.
Right arrow Articles by Truedsson, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received February 4, 2005
Accepted May 17, 2005

6th European Lupus Meeting

Complement and its breakdown products in SLE

G. Sturfelt 1* and L. Truedsson 2

1 Department of Rheumatology, University Hospital of Lund, Lund, Sweden
2 Department of Clinical Microbiology and Immunology, University Hospital of Lund, Lund, Sweden

* To whom correspondence should be addressed.
G. Sturfelt, E-mail: Gunnar.Sturfelt{at}reum.lu.se


  Abstract

The complement system has important protective functions in both the innate and the adaptive immune systems but can also, when inappropriately activated, cause tissue damage. Complement deficiency predisposes to infection and also to development of autoimmune disease, especially SLE, and complement is at the same time involved in the pathogenesis of this disease. In this review, various aspects of this dualism are discussed. An overview of activation pathways and activation products is given, together with a description of autoimmunity against complement and the potential of complement regulation in future therapeutics.

Keywords: Complement; SLE.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Rheumatology (Oxford)Home page
D.-H. Yang, D.-M. Chang, J.-H. Lai, F.-H. Lin, and C.-H. Chen
Usefulness of erythrocyte-bound C4d as a biomarker to predict disease activity in patients with systemic lupus erythematosus
Rheumatology, September 1, 2009; 48(9): 1083 - 1087.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.