Rheumatology Advance Access published online on November 8, 2005
Rheumatology, doi:10.1093/rheumatology/kei079
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1 Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
* To whom correspondence should be addressed. Objectives. To evaluate the relationship between disease damage and bone mineral density (BMD) in women with systemic lupus erythematosus (SLE). Methods. A cross-sectional study was conducted among 307 women with SLE. Patients attended a single clinic visit that included an interview, physical examination, laboratory testing and BMD measurements (hip and/or lumbar spine). Women were stratified by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology cumulative disease damage index (SDI) Results. Mean age at SLE diagnosis was 32.7 ± 11.8 yr, 24.4% were African American, 65.0% were premenopausal, and mean SDI ± s.d. was 1.3 ± 1.8. In the unadjusted and adjusted models controlling for significant univariate risk factors for osteoporosis, the reference group (Group 1) had significantly lower mean BMD T-scores at the hip and lumbar spine than groups having no disease damage (Groups 3 and 4) independent of CS use status. Similar hip and lumbar spine mean BMD T-scores were observed in women with disease damage with and without CS exposure (Groups 1 and 2). Conclusions. Women with SLE having disease damage and no CS use had BMD T-scores at the hip and lumbar spine similar to those of women with disease damage and prior CS use. These findings suggest an association between disease damage and lower BMD T-scores in women with SLE.
Received July 7, 2005
Accepted July 14, 2005
Original Papers
Disease damage and low bone mineral density: an analysis of women with systemic lupus erythematosus ever and never receiving corticosteroids
2 Institute for Healthcare Studies, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
3 Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, PA, USA
4 Department of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
C. Lee, E-mail: c-lee17{at}northwestern.edu
Abstract 
1 (Damage) vs SDI=0 (No Damage), and prior use of corticosteroids (CS), yielding four groups: (1) Damage/CS+ (n=138), (2) Damage/CS- (n=23), (3) no Damage/CS- (n=100), and (4) no Damage/CS- (n=46).
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