Rheumatology Advance Access published online on November 1, 2005
Rheumatology, doi:10.1093/rheumatology/kei082
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Kerckhoff Clinic and Foundation, Department of Rheumatology, Clinical Immunology and Osteology, Bad Nauheim, University of Giessen, Giessen, Germany
* To whom correspondence should be addressed. Objective. To determine the changes in bone mineral density (BMD) in patients with rheumatoid arthritis (RA; without osteoporosis) treated with infliximab. Methods. Twenty-six patients (19 women, seven men) aged 54.2 yr (range 27-75), with persistently active RA despite a high dose of non-steroidal anti-inflammatory drugs and/or treatment with methotrexate or leflunomide, were studied. Mean duration of disease was 9.8 yr. Patients receiving or having received bisphosphonates or hormone replacement therapy were excluded. The patients were treated with 3.5 mg/kg infliximab at weeks 0, 2, 6 and then every 6-8 weeks. Lumbar and femoral BMD was measured by dual-energy X-ray absorptiometry at baseline and 12 months later. Serum osteocalcin and serum crosslaps were measured at baseline (week 0) and after 12 months. Twelve patients were taking calcium (1 g/day) and vitamin D (800 IU/day). Twenty patients were receiving methotrexate (mean dose 12.5 mg/day), six patients were receiving leflunomide (mean dose 20 mg/day) and nine patients were concomitantly receiving corticosteroids at a mean daily dose of 10 mg. Results. After 12 months of infliximab therapy, there was a significant increase in BMD in the spine (BMD, P<0.001; T-score, P<0.001; Z-score, P<0.001) and the femoral neck (BMD, P<0.001; T-score, P<0.001; Z-score, P<0.01). With regard to the root mean square average, there was a significant increase in BMD at the left femoral neck (11.6% for a root mean square of 6%) but only a trend towards improvement in the spine (2.7% for a root mean square of 4%) during the study period. There was a significant increase in osteocalcin serum levels between baseline and after 12 months (P<0.01) and a significant decrease in the marker for bone resorption (P<0.01) but no change in serum calcium was observed. However, the changes in markers of bone metabolism and BMD were not correlated. Conclusion. The data support the hypothesis that anti-TNF therapy may exert beneficial effects on bone metabolism in RA patients.
Received June 22, 2005
Accepted July 19, 2005
Concise Report
Increase in bone mineral density of patients with rheumatoid arthritis treated with anti-TNF-
antibody: a prospective open-label pilot study
2 Medical Clinic C, City Hospital Ludwigshafen, Ludwigshafen, Germany
U. Lange, E-mail: U.Lange{at}kerckhoff-klinik.de
Abstract 
therapy.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M Guler-Yuksel, C F Allaart, Y P M Goekoop-Ruiterman, J K de Vries-Bouwstra, J H L M van Groenendael, C Mallee, M H W de Bois, F C Breedveld, B A C Dijkmans, and W F Lems Changes in hand and generalised bone mineral density in patients with recent-onset rheumatoid arthritis Ann Rheum Dis, March 1, 2009; 68(3): 330 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Visvanathan, D van der Heijde, A Deodhar, C Wagner, D G Baker, J Han, and J Braun Effects of infliximab on markers of inflammation and bone turnover and associations with bone mineral density in patients with ankylosing spondylitis Ann Rheum Dis, February 1, 2009; 68(2): 175 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Guler-Yuksel, J Bijsterbosch, Y P M Goekoop-Ruiterman, J K de Vries-Bouwstra, H M J Hulsmans, W M de Beus, K H Han, F C Breedveld, B A C Dijkmans, C F Allaart, et al. Changes in bone mineral density in patients with recent onset, active rheumatoid arthritis Ann Rheum Dis, June 1, 2008; 67(6): 823 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Chopin, P Garnero, A le Henanff, F Debiais, A Daragon, C Roux, J Sany, D Wendling, C Zarnitsky, P Ravaud, et al. Long-term effects of infliximab on bone and cartilage turnover markers in patients with rheumatoid arthritis Ann Rheum Dis, March 1, 2008; 67(3): 353 - 357. [Abstract] [Full Text] [PDF]
|
|