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Rheumatology Advance Access published online on September 7, 2005
Rheumatology, doi:10.1093/rheumatology/kei091
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© The Author 2005. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received March 22, 2005
Accepted August 1, 2005

Review Article

The pathophysiology of the growth plate in juvenile idiopathic arthritis

V. E. MacRae 1, C. Farquharson 2, and S. F. Ahmed 3*

1 Bone Biology Group, Division of Gene Function and Development, Roslin Institute, Edinburgh, UK; Bone and Endocrine Research Group, Royal Hospital for Sick Children, Glasgow, UK
2 Bone Biology Group, Division of Gene Function and Development, Roslin Institute, Edinburgh, UK
3 Bone and Endocrine Research Group, Royal Hospital for Sick Children, Glasgow, UK

* To whom correspondence should be addressed.
S. F. Ahmed, E-mail: gcl328{at}clinmed.gla.ac.uk


  Abstract

Children with chronic inflammatory diseases, such as juvenile idiopathic arthritis (JIA), suffer from a variety of growth disorders. These range from general growth retardation to local acceleration of growth in the affected limb. These disorders are associated with the increased production of proinflammatory cytokines, which may influence growth through a local effect in the growth plates of long bones and/or systemic effects throughout the whole body. In this article we review these aspects and also discuss the evidence for interaction between the inflammatory cytokine and growth-signalling pathways.


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