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Rheumatology Advance Access published online on January 31, 2006
Rheumatology, doi:10.1093/rheumatology/kel023
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received November 13, 2005
Accepted January 6, 2006

Concise Report

Association between PADI4 and rheumatoid arthritis: a meta-analysis

T. Iwamoto 1, K. Ikari 2 *, T. Nakamura 3, M. Kuwahara 2, Y. Toyama 4, T. Tomatsu 2, S. Momohara 2, and N. Kamatani 2

1 Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan; Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan
2 Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
3 Laboratory for Statistical Analysis, SNP Research Center, Institute of Physical and Chemical Research (RIKEN), Tokyo, Japan
4 Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan

* To whom correspondence should be addressed.
K. Ikari, E-mail: kikari{at}ior.twmu.ac.jp


  Abstract

Objective. Polymorphisms and haplotypes of the peptidylarginine deiminase type 4 gene (PADI4) have been reported to be associated with rheumatoid arthritis (RA) in a Japanese population. However, subsequent replication studies showed conflicting results. The aim of this study was to determine whether meta-analysis would prove the existence of the association.

Methods. PubMed was searched using the term ‘PADI4’ for articles from the publication of the first study to December 2005. Replication studies that tested the association between PADI4 and RA were reviewed for meta-analysis. The Breslow-Day test for homogeneity across the studies was calculated. The Mantel-Haenszel procedure was used to pool odds ratios (OR) with 95% confidence intervals (CI) to evaluate the association.

Results. Six replication studies, one from Japan and five from Europe and North America, fulfilled the selection criteria for inclusion in the meta-analysis. Homogeneity was confirmed across the replication studies. The common OR was 1.14 (95% CI = 1.07-1.21) for allelic distribution. The association was confirmed when only five replication studies in the European descent populations were combined (P = 0.0096, common OR = 1.10).

Conclusions. Our meta-analysis showed a positive association between PADI4 and RA not only in the Japanese population but also in populations of European descent.

Keywords: rheumatoid arthritis; PADI4; Population genetics; Susceptibility; Meta-analysis..
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