Skip Navigation



Rheumatology Advance Access published online on March 29, 2006
Rheumatology, doi:10.1093/rheumatology/kel089
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
45/10/1210    most recent
kel089v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Lawson, C. A.
Right arrow Articles by Isaacs, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lawson, C. A.
Right arrow Articles by Isaacs, J. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received October 17, 2005
Accepted February 14, 2006

Original Papers

Early rheumatoid arthritis is associated with a deficit in the CD4+CD25high regulatory T cell population in peripheral blood

C. A. Lawson 1 *, A. K. Brown 2, V. Bejarano 2, S. H. Douglas 3, C. H. Burgoyne 1, A. S. Greenstein 2, A. W. Boylston 3, P. Emery 2, F. Ponchel 1, and J. D. Isaacs 4

1 Academic Unit of Musculoskeletal Disease, IMMECR, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK; Molecular Medicine Unit, Clinical Sciences Building, St James's University Hospital, Leeds LS9 7TF, UK
2 Academic Unit of Musculoskeletal Disease, IMMECR, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK
3 Molecular Medicine Unit, Clinical Sciences Building, St James's University Hospital, Leeds LS9 7TF, UK
4 Musculoskeletal Research Group, School of Clinical Medical Sciences, The Medical School, Framlington Place, Newcastle-Upon-Tyne NE2 4HH, UK

* To whom correspondence should be addressed.
C. A. Lawson, E-mail: medcl{at}leeds.ac.uk


  Abstract

Objective. Our aim was to test the hypothesis that there is a deficit in the CD4+CD25high regulatory T-cell population in early rheumatoid arthritis (RA), either in size or functional activity.

Methods. Peripheral blood mononuclear cells were examined from subjects with early active RA who had received no previous disease-modifying therapy (n = 43), from individuals with self-limiting reactive arthritis (n = 14), from subjects with stable, well-controlled RA (n = 82) and from healthy controls (n = 72). The frequencies of CD4+CD25high T-cells were quantified using flow cytometry, and function was assessed by the ability to suppress proliferation of CD4+CD25- T-cells. Paired blood and synovial fluid was analysed from a small number of RA and reactive arthritis patients.

Results. There was a smaller proportion of CD4+CD25high T-cells in the peripheral blood of early active RA patients (mean 4.25%) than in patients with reactive arthritis or in controls (mean 5.90 and 5.30%, respectively, P = 0.001 in each case). Frequencies in stable, well-controlled RA (mean 4.63%) were not significantly different from early active RA or controls. There were no differences in suppressor function between groups. Higher frequencies of CD4+CD25high T-cells were found in synovial fluid than blood in both RA and reactive arthritis.

Conclusions. These data demonstrate a smaller CD4+CD25high regulatory T-cell population in peripheral blood of individuals with early active RA prior to disease-modifying treatment. This may be a contributory factor in the susceptibility to RA and suggests novel approaches to therapy.

Keywords: CD4+CD25high T-cells; Regulatory T-cells; Early arthritis; Rheumatoid arthritis; Reactive arthritis..
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Rheumatology (Oxford)Home page
J. D. Isaacs
Therapeutic T-cell manipulation in rheumatoid arthritis: past, present and future
Rheumatology, October 1, 2008; 47(10): 1461 - 1468.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
L. Chen, P. Yang, H. Zhou, H. He, X. Ren, W. Chi, L. Wang, and A. Kijlstra
Diminished Frequency and Function of CD4+CD25high Regulatory T Cells Associated with Active Uveitis in Vogt-Koyanagi-Harada Syndrome
Invest. Ophthalmol. Vis. Sci., August 1, 2008; 49(8): 3475 - 3482.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
F Forger, N Marcoli, S Gadola, B Moller, P M Villiger, and M Ostensen
Pregnancy induces numerical and functional changes of CD4+CD25high regulatory T cells in patients with rheumatoid arthritis
Ann Rheum Dis, July 1, 2008; 67(7): 984 - 990.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
F. Behrens, A. Himsel, S. Rehart, J. Stanczyk, B. Beutel, S. Y Zimmermann, U. Koehl, B. Moller, S. Gay, J. P Kaltwasser, et al.
Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis
Ann Rheum Dis, September 1, 2007; 66(9): 1151 - 1156.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Arruvito, M. Sanz, A. H. Banham, and L. Fainboim
Expansion of CD4+CD25+and FOXP3+ Regulatory T Cells during the Follicular Phase of the Menstrual Cycle: Implications for Human Reproduction
J. Immunol., February 15, 2007; 178(4): 2572 - 2578.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.