Rheumatology Advance Access published online on April 7, 2006
Rheumatology, doi:10.1093/rheumatology/kel123
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1 Rheumatology Department, University Hospital, Nice, France
* To whom correspondence should be addressed. Objective. To assess the safety of anti-tumour necrosis factor (TNF)- Methods. Records concerning 480 outpatients attending the Rheumatology Department of the University Hospital of Nice (France) for RA or SA were retrospectively reviewed for the duration of disease, treatment, serological status and biological data. Results. Six relevant cases were identified: two of RA with chronic hepatitis B; one of SA with chronic hepatitis B and three of RA with chronic hepatitis C. Five patients had received etanercept and one infliximab; two had been given adalimumab after an unsuccessful trial of etanercept. Patients with concurrent chronic hepatitis B were also given lamivudine. In none of the cases had changes in serum aminotransferases or viral load been reported. Conclusion. The use of anti-TNF-
Received December 26, 2005
Accepted March 15, 2006
Original Papers
Safety of anti-TNF-
C. H. Roux 1 *,
O. Brocq 1,
V. Breuil 1,
C. Albert 1,
and
L. Euller-Ziegler 1
therapy in rheumatoid arthritis and spondylarthropathies with concurrent B or C chronic hepatitis
C. H. Roux, E-mail: roux101fr{at}yahoo.fr
Abstract 
therapy in patients with rheumatoid arthritis (RA) or spondylarthropathies (SA) and concurrent chronic hepatitis B or C. therapy (plus lamivudine in the presence of concurrent underlying hepatitis B viral infection) appeared to be safe in that it had no effect on serum aminotransferases and/or viral load. However, repeated monitoring is necessary throughout the treatment period. treatment.
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