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Rheumatology Advance Access published online on May 16, 2006
Rheumatology, doi:10.1093/rheumatology/kel142
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received November 2, 2005
Accepted February 27, 2006

Review

Macrophage migration inhibitory factor and glucocorticoid sensitivity

D. Aeberli 1, M. Leech 1, and E. F. Morand 1 *

1 Centre for Inflammatory Diseases, Monash Institute for Medical Research, Monash Medical Centre, Clayton, Melbourne, Australia

* To whom correspondence should be addressed.
E. F. Morand, E-mail: eric.morand{at}med.monash.edu.au


  Abstract

Glucocorticoids (GCs) are widely used in the treatment of inflammatory diseases including rheumatoid arthritis (RA). Treatment with GC is associated with significant dose-dependent side-effects. The pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) has emerged in recent years as a candidate factor which could regulate GC sensitivity. MIF is induced by GC, and is able to override anti-inflammatory actions of GCs. In this review, we summarize the pro-inflammatory actions of MIF with respect to RA, describe the interactions between MIF and GC and examine new evidence, which identifies MIF as a specific target for steroid sparing.

Keywords: MIF; Glucocorticoids; Steroid sparing; Rheumatoid arthritis.
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