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Rheumatology Advance Access published online on August 27, 2006
Rheumatology, doi:10.1093/rheumatology/kel207
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received January 12, 2006
Accepted May 12, 2006

Review

Acupuncture for peripheral joint osteoarthritis: A systematic review and meta-analysis

Y. D. Kwon 1, M. H. Pittler 2 *, and E. Ernst 2

1 Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, UK; Department of Rehabilitation and Acupuncture, School of Oriental Medicine, Wonkwang University, South Korea
2 Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, UK

* To whom correspondence should be addressed.
M. H. Pittler, E-mail: max.pittler{at}pms.ac.uk


  Abstract

Objective. To evaluate the evidence for the effectiveness of acupuncture in peripheral joint osteoarthritis (OA).

Methods. Systematic searches were conducted on Medline, Embase, AMED, Cochrane Library, CINAHL, British Nursing Index, PsychINFO and CAMPAIN until July 2005. Hand-searches included conference proceedings and our own files. There were no restrictions regarding the language of publication. All randomized controlled trials (RCTs) of acupuncture for patients with peripheral joint OA were considered for inclusion. Trials assessing needle acupuncture with or without electrical stimulation were considered if sham- or placebo-controlled or controlled against a comparator intervention. Trials testing other forms of acupuncture were excluded. Methodological quality was assessed and, where possible, meta-analyses were performed.

Results. Thirty-one possibly relevant studies were identified and 18 RCTs were included. Ten trials tested manual acupuncture and eight trials tested electro-acupuncture. Overall, ten studies demonstrated greater pain reduction in acupuncture groups compared with controls. The meta-analysis of homogeneous data showed a significant effect of manual acupuncture compared with sham acupuncture (standardized mean difference 0.24, 95% confidence interval 0.01-0.47, P = 0.04, n = 329), which is supported by data for knee OA. The extent of heterogeneity in trials of electro-acupuncture prevented a meaningful meta-analysis.

Conclusions. Sham-controlled RCTs suggest specific effects of acupuncture for pain control in patients with peripheral joint OA. Considering its favourable safety profile acupuncture seems an option worthy of consideration particularly for knee OA. Further studies are required particularly for manual or electro-acupuncture in hip OA.

Keywords: Acupuncture; Osteoarthritis; Randomized controlled trial; Systematic review.
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