Rheumatology Advance Access published online on July 31, 2006
Rheumatology, doi:10.1093/rheumatology/kel222
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1 Department of Medicine, Division of Clinical Immunology and Rheumatology, Birmingham, AL, USA
* To whom correspondence should be addressed. Objective. To determine the impact of pregnancy on systemic lupus erythematosus (SLE) outcome. Methods. SLE patients, age Results. Sixty-three SLE women from all ethnic groups were included. The mean (s.d.) age and disease duration at pregnancy outcome were 27.6 (6.5) yrs and 18.3 (22.5) months, respectively. Adverse pregnancy outcomes occurred in 76.2% women. The SLAM-R and SDI scores were statistically different after pregnancy (P = 0.050 and P < 0.001, respectively); the SDI score was independent of pregnancy outcome but strongly associated with pregnancy duration (P = 0.006), disease activity (P = 0.001), damage prior to pregnancy (P < 0.001) and total disease duration (P = 0.039) by multivariable analyses. Exposure to pregnancy itself did not impact on damage accrual in the case-crossover analyses of 142 patients (17 pregnancy exposures) (OR = 1.25; 95% CI 0.336-4.655; P = 0.480). Conclusions. Pregnancy duration, total disease duration, disease activity and damage immediately prior to pregnancy decisively impact on damage accrual after pregnancy in patients with SLE. Supported by Grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases #R01-AR42503 and General Clinical Research Centers #M01-RR02558 (UTH-HSC) and M01-RR00032 (UAB) and from the National Center for Research Resources (NCRR/NIH) RCMI Clinical Research Infrastructure Initiative (RCRII) award 1P20RR11126 (UPR-MSC), The Mary Kirkland Scholars Award Program (UAB), and Rheuminations, Inc. (UAB)
Received May 3, 2006
Accepted May 16, 2006
Original Papers
Predictors of post-partum damage accrual in systemic lupus erythematosus: data from LUMINA, a multiethnic US cohort (XXXVIII)
R. M. Andrade 1, G. McGwin Jr 2, G. S. Alarcón 1 *, M. L. Sanchez 1, A. M. Bertoli 1, M. Fernández 1, B. J. Fessler 1, M. Apte 1, A. M. Arango 3, H. M. Bastian 1, L. M. Vilá 4, and J. D. Reveille 3, for the LUMINA Study Group
2 Department of Epidemiology, Section of Trauma, Burns, and Critical Care, Schools of Medicine and Public Health, The University of Alabama at Birmingham, Birmingham, AL, USA; Department of Surgery, Section of Trauma, Burns, and Critical Care, Schools of Medicine and Public Health, The University of Alabama at Birmingham, Birmingham, AL, USA
3 Department of Medicine, Division of Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX, USA
4 Department of Internal Medicine, Division of Rheumatology, The University of Puerto Rico Medical Sciences Campus, San Juan, PR, USA
G. S. Alarcón, E-mail: graciela.alarcon{at}ccc.uab.edu
Abstract 
16 yrs, disease duration 
5 yrs at enrolment in LUMINA, a multiethnic cohort (Hispanics, African-Americans and Caucasians), were studied. The first pregnancy after SLE diagnosis was examined. A good pregnancy outcome was a full-term delivery; an adverse outcome was a miscarriage, abortion, premature birth or stillbirth. Dependent variables were disease activity (Systemic Lupus Activity Measure-Revised, SLAM-R) and damage accrual [Systemic Lupus International Collaborating Clinics (SLICC) Damage Index, SDI]. Differences in these variables between the visit immediately prior to, and the first visit after, pregnancy and their relationship with pregnancy outcome were examined. Damage accrual due to pregnancy exposure was examined by a case-crossover design.
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