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Rheumatology Advance Access published online on August 5, 2006
Rheumatology, doi:10.1093/rheumatology/kel263
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received January 31, 2006
Accepted June 27, 2006

Original Papers

Lack of bone stiffness/strength contribution to osteoarthritis--evidence for primary role of cartilage damage

B. M. Rothschild 1 * and R. K. Panza 2

1 Arthritis Center of Northeast Ohio, 5500 Market, Youngstown, OH 44512, USA; Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44512, USA; Carnegie Museum of Natural History, 4400 Forbes Ave, Pittsburgh, PA 15213, USA; Dyche Hall, University of Kansas Museum of Natural History, Lawrence, KS 66044, USA
2 Carnegie Museum of Natural History, 4400 Forbes Ave, Pittsburgh, PA 15213, USA

* To whom correspondence should be addressed.
B. M. Rothschild, E-mail: bmr{at}neoucom.edu


  Abstract

Objectives. This study was performed to assess osseous contributions to osteoarthritis, obviating the analysis challenges presented by confounding factors in humans and rarity of osteoarthritis in free-ranging mammals.

Methods. Frequency of osteoarthritis in 21 bird species was examined and contrasted with measures of afflicted element bone stiffness and strength and compression/tension-resistant characteristics.

Results. Osteoarthritis was present in the ankle of 0-16% of bird species analysed, independent of bone laminarity, cortical thickness, circularity, polarization, cross-sectional diameter, length and pneumatization.

Conclusions. No correlation of frequency of osteoarthritis with parameters of bone strength and biomechanical parameters was found, suggesting that bone is only secondarily affected in osteoarthritis and that cartilage is the initial target of the disease.

Keywords: Osteoarthritis; Animal model.

The corresponding author verifies that the co-author has contributed to the work but that the author is non-contactable.


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