Skip Navigation



Rheumatology Advance Access published online on September 26, 2006
Rheumatology, doi:10.1093/rheumatology/kel302
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
46/3/523    most recent
kel302v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Huffman, K. M.
Right arrow Articles by Kraus, V. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huffman, K. M.
Right arrow Articles by Kraus, V. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received April 17, 2006
Accepted July 18, 2006

Concise Report

Synovial fluid metabolites in osteonecrosis

K. M. Huffman 1, J. R. Bowers 2, Z. Dailiana 3, J. L. Huebner 4, J. R. Urbaniak 2, and V. B. Kraus 4 *

1 Physical Medicine and Rehabilitation Service, Durham Veterans Affairs Medical Center, Durham, NC, USA
2 Department of Orthopedic Surgery, Duke University Medical Center, Durham, NC, USA
3 Department of Orthopaedic Surgery, Medical School, University of Thessalia, 41222 Larissa, Greece
4 Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham NC, USA

* To whom correspondence should be addressed.
V. B. Kraus, E-mail: vbk{at}duke.edu


  Abstract

Objectives. Osteonecrosis of the femoral head results from interruption of the vascular supply and eventual death of the cellular portion of bone. Effective methods of monitoring response to treatment are needed. Our aim was to evaluate synovial fluid metabolites, glucose and lactate, as biomarkers in a canine model of osteonecrosis.

Methods. Osteonecrosis was cryosurgically induced in the right femoral head while the left hip served as control (n = 31). Animals either underwent no further intervention (n = 10), vascular endothelial growth factor (VEGF) injections (n = 4), placement of a vascularized bone graft (n = 6), a combination of VEGF microinjection and vascularized graft placement (n = 5), or treatment with daily oral alendronate (n = 6). After 12 weeks, synovial fluid from each hip joint was obtained for glucose and lactate concentrations.

Results. Joints with surgically induced osteonecrosis demonstrated decreased synovial fluid concentrations of glucose (P < 0.05) and elevated concentrations of lactate (P < 0.05) relative to contralateral control hips. When animals were treated with VEGF, the vascularized graft placement, or vascularized graft and VEGF, there were no differences in the synovial fluid concentrations of these metabolites between cryoablated and control hips. In contrast, alendronate did not normalize the concentration of these synovial fluid metabolites in the cryoablated hips.

Conclusions. Osteonecrosis of the femoral head is associated with alterations in synovial fluid glucose and lactate, reflecting anaerobic metabolism. These metabolites may serve as useful tools for monitoring response to revascularization therapies.

Keywords: Osteonecrosis; Synovial fluid; Synovial fluid metabolites; Glucose; Lactate; Vascular endothelial growth factor; Vascularized bone graft; Alendronate; Canine model.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.