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Rheumatology Advance Access published online on October 25, 2006
Rheumatology, doi:10.1093/rheumatology/kel352
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© The Author 2006. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received July 11, 2006
Accepted September 12, 2006

Review

Therapeutic status of radiosynoviorthesis of the knee with yttrium [90Y] colloid in rheumatoid arthritis and related indications

W. U. Kampen 1, M. Voth 2, J. Pinkert 2, and A. Krause 3 *

1 Clinic of Nuclear Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Germany
2 Schering, Berlin, Germany
3 Rheumatology, Immanuel-Krankenhaus, Germany

* To whom correspondence should be addressed.
A. Krause, E-mail: A.Krause{at}immanuel.de


  Abstract

Radiosynoviorthesis (RSO) with an yttrium-90 colloid offers a local and minimally invasive therapy for treating inflammatory hypertrophy of the synovial membrane of the knee that has arisen from numerous kinds of disorder: these include rheumatoid arthritis (RA), osteoarthritis (OA), spondyloarthropathy, villonodular synovitis and others. There is substantial evidence that this treatment is efficacious and that, in view of the benefits that it offers, its tolerability and safety are very good. Administration should be restricted to patients in whom other therapies (including locally injected corticoids) have failed, and proper attention must be paid to correct administration, including post-treatment immobilization and the co-administration of corticoids, to minimize the risk of leakage and of efflux through the puncture channel.

Keywords: Radiosynoviorthesis; Yttrium-90 colloid; Rheumatoid arthritis; Osteoarthritis; Synovitis.
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R. Klett, U. Lange, H. Haas, M. Voth, and J. Pinkert
Radiosynoviorthesis of medium-sized joints with rhenium-186-sulphide colloid: a review of the literature
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[Abstract] [Full Text] [PDF]


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