Skip Navigation


Rheumatology Advance Access first published online on June 24, 2007
This version published online on July 12, 2007
Rheumatology, doi:10.1093/rheumatology/kem154
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
46/10/1525    most recent
kem154v2
kem154v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Tenbrock, K.
Right arrow Articles by Tsokos, G. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tenbrock, K.
Right arrow Articles by Tsokos, G. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Review

Altered signal transduction in SLE T cells

K. Tenbrock1, Y.-T. Juang2, V. C. Kyttaris2 and G. C. Tsokos2

1Department of Pediatrics, Division of Rheumatology, University Hospital Muenster, 48145 Muenster, Germany and 2Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

Correspondence to: Klaus Tenbrock, University of Münster, Department of Pediatrics, Division of Rheumatology, Institute of Experimental Dermatology, Röntgenstr. 21 D-48149 Münster, Germany. E-mail: ktenbroc{at}uni-muenster.de


  Abstract

T cells from patients with systemic lupus erythematosus display numerous signalling abnormalities. The T cell receptor complex is rewired with the common FcR{gamma} chain replacing the CD3 {zeta} chain while the T cell surface membrane lipid rafts are aggregated. These two aberrations result in enhanced early signalling events and altered downstream signalling events. These are in turn responsible for an altered expression of cytokines such as interleukin-6 (IL-6), IL-10, IL-2, IFNy and CD40 ligand. While some of these abnormalities explain the enhanced ability of T cells to help B cells to produce autoantibodies, decreased IL-2 production results in enhanced susceptibility to infections, reduced activation-induced cell death and prolonged survival of autoreactive T cells, which promote help to autoreactive B cells.

KEY WORDS: lupus, CREM, CamKIV, Elf-1, NFAT, AP-1

Submitted 30 January 2007; revised version accepted 3 May 2007.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.