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Rheumatology Advance Access published online on June 30, 2007
Rheumatology, doi:10.1093/rheumatology/kem170
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Maternal exposure to leflunomide associated with blindness and cerebral palsy

C. E. Neville and J. McNally1

Department of Rheumatology, Stoke Mandeville Hospital, Aylesbury, Buckinghamshire and 1Department of Rheumatology, Royal Berkshire and Battle Hospitals NHS Trust, Reading, Berkshire, UK

Correspondence to: Dr C. Neville, Department of Rheumatology, Stoke Mandeville Hospital, Mandeville Road, Aylesbury, Buckinghamshire, HP21 8AL, UK. E-mail: cai_neville@yahoo.co.uk

The first 10% of the full text of this article appears below.

SIR, We report the case of a 43-year-old woman with sero-positive nodular erosive rheumatoid arthritis who became pregnant whilst taking leflunomide. The drug was only stopped after 16 weeks of gestation.

Leflunomide has been reported to cause teratogenic effects in animals. Fetal death, anopthalmia, . . . [Full Text of this Article]


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