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Rheumatology Advance Access published online on September 1, 2007
Rheumatology, doi:10.1093/rheumatology/kem208
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© The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

A case of Raynaud's phenomenon in mixed connective tissue disease responding to Rituximab therapy—response

L. Dunkley, M. Green and A. Gough

Department of Rheumatology, Harrogate Health Care NHS Trust, Lancaster Park Road, Harrogate HG2 7SX, UK

Correspondence to: Dr Mike Green, Consultant Rheumatologist, Harrogate Health Care NHS Trust, Lancaster Park Road, Harrogate HG2 7SX, UK. E-mail: mike.green@hdft.nhs.uk

The first 10% of the full text of this article appears below.

SIR, We wish to respond to the recent case report of a patient with mixed connective tissue disease whose Raynaud's phenomenon responded to Rituximab therapy [1]. We would like to report a patient with undifferentiated, anti-nuclear antibody (ANA)-positive, connective tissue disease whose Raynaud's phenomenon did not respond to Rituximab.

A 32-yr-old woman presented in 2004 with severe triphasic Raynaud's, livedo, large joint arthralgia and a strongly positive ANA (nucleolar staining, 1: 1600 titre). She . . . [Full Text of this Article]


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