Skip Navigation



Rheumatology Advance Access published online on September 25, 2007
Rheumatology, doi:10.1093/rheumatology/kem254
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
46/12/1858    most recent
kem254v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Yamamoto, M.
Right arrow Articles by Shinomura, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamamoto, M.
Right arrow Articles by Shinomura, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Letter to the Editor

Cartilage oligomeric matrix protein in systemic sclerosis

M. Yamamoto, H. Takahashi, C. Suzuki, Y. Naishiro, H. Yamamoto, K. Imai1 and Y. Shinomura

First Department of Internal Medicine, Sapporo Medical University School of Medicine 1Sapporo Medical University, Japan

Correspondence to: Motohisa Yamamoto, First Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1- West 16, Chuo-ku, Sapporo, Hokkaido, 0608543, Japan. E-mail: mocha@cocoa.plala.or.jp

The first 10% of the full text of this article appears below.

SIR, Few biomarkers of systemic sclerosis (SSc) are useful, so physicians must largely depend on physical findings. However, we found that cartilage oligomeric matrix protein (COMP) appears clinically informative in patients with SSc. Here, we describe the relationship between COMP and SSc.

COMP is an extracellular glycoprotein belonging to the thrombospondin gene family that forms a disulfide-linked pentamer and is predominantly found in cartilage, tendons, ligaments and bone growth plates. COMP binds to type II collagen fibres and stabilizes . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?