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Rheumatology Advance Access published online on July 15, 2008
Rheumatology, doi:10.1093/rheumatology/ken240
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Tolerability of methotrexate and leflunomide combination therapy for inflammatory arthritis in routine clinical practice: results of a four-centre study

A. Kaul1, D. T. O’Reilly2, R. K. Slack2, D. Collins3, J. Walmsley4, O. Duke4 and P. D. W. Kiely1

1St George's Healthcare NHS Trust, London, 2West Suffolk Hospital, Bury St Edmonds, 3Great Western Hospital, Swindon and 4Epsom and St Helier NHS Trust, Epsom, UK

Correspondence to: A. Kaul, Department of Rheumatology, Royal Free Hospital, Pond Street, London NW3 2QG, UK. E-mail: arvind.kaul@royalfree.nhs.uk

The first 10% of the full text of this article appears below.

SIR, Combination DMARD therapy is increasingly used for the treatment of inflammatory arthritis because monotherapy often does not produce remission [1]. The contrasting modes of action of MTX and LEF make them attractive candidates for use in combination [2] with the potential to provide additive or synergistic actions, perhaps without the need for expensive biologic agents [3].

Although combination DMARDs in early RA confer long-term structural advantages [4,5], meta-analysis of clinical trial . . . [Full Text of this Article]


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