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Rheumatology Advance Access published online on July 25, 2008
Rheumatology, doi:10.1093/rheumatology/ken301
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© The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Editorial

Issues with vitamin D in routine clinical practice

B. J. Jones1 and P. J. Twomey1

1Department of Clinical Biochemistry, The Ipswich Hospital, Ipswich, UK

Correspondence to: P. J. Twomey, Department of Clinical Biochemistry, The Ipswich Hospital, Ipswich, Suffolk IP4 5PD, UK. E-mail: ptwomey@nhs.net

The first 150 words of the full text of this article appear below.

It is a good time to be involved with vitamin D. Under-recognized for so long, the past few years have seen a flurry of research activity and the realization that this prohormone and its metabolites are involved in far more than just calcium and bone metabolism. Perhaps this is not that surprising when one considers that the vitamin D receptor is expressed in a wide variety of body tissues, including brain, heart, skin, gut, gonads, prostate, breast and immune cells, as well as bone, intestine, kidney and parathyroid [1]. Correspondingly, vitamin D deficiency has been linked to an increased risk of a number of malignancies, cardiovascular disease, depression, schizophrenia and autoimmune and inflammatory disease [2]. Of course, rheumatologists have known about the key role of vitamin D in bone disease for a long time, and thus it is perhaps surprising that the exciting discovery of a . . . [Full Text of this Article]


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